Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.55 |
| ▸ | MMP9 | P14780 | 5/20 | 0.55 |
| ▸ | MMP13 | P45452 | 5/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6290684 | 0.83 | MMP1 (0.73) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL6290652 | 0.79 | MMP1 (0.57) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL6289966 | 0.79 | LMNA (0.43) | MMP1MMP9MMP13LMNAPOLB | |
| SCHEMBL6290602 | 0.74 | MMP1 (0.49) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL6290580 | 0.73 | MMP1 (0.80) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL6293913 | 0.72 | MMP1 (0.56) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL6289511 | 0.71 | MMP1 (0.48) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL6290776 | 0.71 | MMP1 (0.56) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL6290788 | 0.71 | MMP1 (0.54) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL7008670 | 0.70 | MMP9 (0.77) | MMP1MMP9MMP13ADAM17LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1279674-A2 | Acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors | American Cyanamid Company (US) | 2003-01-29 | — | — | EP | disclosed |
| EP-1157024-A1 | ACETYLENIC ORTHO-SULFONAMIDO AND PHOSPHINIC ACID AMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000044749-A1 | ACETYLENIC ORTHO-SULFONAMIDO AND PHOSPHINIC ACID AMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |