Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399108 | 0.84 | PARP1 (0.39) | LMNATPSAB1 | |
| SCHEMBL4395889 | 0.83 | BCL2 (0.39) | LMNATP53TPSAB1ALOX12 | |
| SCHEMBL4405962 | 0.82 | GRM5 (0.40) | TPSAB1 | |
| SCHEMBL4412034 | 0.82 | LMNA (0.40) | SLC2A1LMNATPSAB1 | |
| SCHEMBL4399105 | 0.81 | TPSAB1 (0.38) | LMNATPSAB1 | |
| SCHEMBL4406792 | 0.81 | JAK2 (0.41) | TPSAB1 | |
| SCHEMBL4405326 | 0.80 | PDK1 (0.41) | SLC2A1LMNATPSAB1 | |
| SCHEMBL4396163 | 0.80 | CHRM2 (0.39) | LMNA | |
| SCHEMBL4404630 | 0.80 | LMNA (0.38) | SLC2A1LMNATP53TPSAB1 | |
| SCHEMBL4397958 | 0.79 | ACACB (0.42) | LMNATPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |