Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TERT | O14746 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867321 | 0.90 | ALOX15 (0.49) | ALOX15SIGMAR1POLBCYP1A2CYP3A4 | |
| SCHEMBL7278898 | 0.83 | ALOX15 (0.76) | ALOX15CYP2C9HPGDNAMPTHTR1D | |
| SCHEMBL7455224 | 0.83 | ALOX15 (0.55) | ALOX15TERTSIGMAR1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL28306930 | 0.81 | ALOX15 (0.53) | ALOX15TERTSIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL27278945 | 0.81 | ALOX15 (0.53) | ALOX15TERTSIGMAR1CYP3A4CYP2D6 | |
| SCHEMBL18325474 | 0.78 | ALOX15 (0.67) | ALOX15CYP2C9HPGDHTR1DHTR1B | |
| Bicarbonate SCHEMBL28339489 | 0.76 | TBXAS1 (0.48) | ALOX15TERTSIGMAR1CYP1A2CYP3A4 | |
| Formic Acid SCHEMBL28874959 | 0.75 | ALOX15 (0.46) | ALOX15TERTSIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL6930591 | 0.75 | ALOX15 (0.46) | ALOX15POLBHPGDALDH1A1 | |
| SCHEMBL9866240 | 0.75 | ALOX15 (0.53) | ALOX15TERTTBXAS1HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |