Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | CCR4 | P51679 | 5/20 | 0.44 |
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | ECE1 | P42892 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5415716 | 1.00 | MMP9 (0.47) | MMP9CCR4MMEACEECE1 | |
| SCHEMBL5406228 | 0.84 | MMP1 (0.49) | MMP9CCR4MMEACEECE1 | |
| SCHEMBL5722976 | 0.84 | CCR4 (0.45) | MMP9CCR4MMEACEECE1 | |
| SCHEMBL6979587 | 0.84 | MMP1 (0.49) | MMP9CCR4MMEACEECE1 | |
| SCHEMBL5420131 | 0.84 | CCR4 (0.45) | MMP9CCR4MMEACEECE1 | |
| SCHEMBL7138127 | 0.84 | CCR4 (0.45) | MMP9CCR4MMEACEECE1 | |
| SCHEMBL5415738 | 0.81 | MMP9 (0.41) | MMP9CCR4ECE1MMP1MMP3 | |
| SCHEMBL5404212 | 0.78 | LMNA (0.44) | CCR4MMEACEECE1AKR1C3 | |
| SCHEMBL5404204 | 0.78 | LMNA (0.44) | CCR4MMEACEECE1AKR1C3 | |
| SCHEMBL5415765 | 0.77 | MMP1 (0.47) | MMP9MMEACEECE1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |