Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146081 | 0.91 | HDAC3 (0.50) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL13141005 | 0.84 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL12838390 | 0.83 | HDAC3 (0.58) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL31346687 | 0.83 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2653117 | 0.81 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL5736276 | 0.81 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL7018973 | 0.80 | HDAC3 (0.73) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL6848383 | 0.80 | HDAC3 (0.55) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL6814615 | 0.80 | HDAC3 (0.55) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2653869 | 0.79 | HDAC3 (0.54) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301505-A2 | THIOPHENE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-16 | — | — | EP | disclosed |
| US-6403810-B2 | RESPIRATORY SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2002-06-11 | — | — | US | disclosed |
| US-20020019438-A1 | Thiophene derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-14 | — | — | US | disclosed |
| WO-2002004439-A2 | THIOPHENE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019438-A1 | Thiophene derivatives | RARG, RARA, RARB | HDAC3 1289/4885HDAC4 1524/4885HDAC1 2034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.