Thialbarbital

Thialbarbital

SCHEMBL714643

C=CCC1([C@@H]2C=CCCC2)C(=O)NC(=S)NC1=O

nearest known ligand 0.32

Full drug profile on Sugi Atlas →

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thialbarbital SCHEMBL714642 1.00 ALDH1A1 (0.32) ALDH1A1
Thialbarbital SCHEMBL11110725 1.00 ALDH1A1 (0.32) ALDH1A1
Thialbarbital SCHEMBL19436260 0.99 ALDH1A1 (0.31) ALDH1A1
Thialbarbital SCHEMBL1004175 0.84 MMP9 (0.45)
SCHEMBL1642994 0.82 MMP9 (0.35)
SCHEMBL713311 0.82 MMP9 (0.35)
SCHEMBL9452872 0.81 MMP9 (0.34)
Hydrochloric Acid SCHEMBL16927556 0.81 MMP9 (0.34)
Cyclobarbital SCHEMBL7617865 0.69 MEN1 (0.31)
SCHEMBL8822651 0.63 GAA (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 474 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240099995-A1 METHOD OF PREPARING A TOPICAL PHARMACEUTICAL COMPOSITION PHEBRA PTY LTD (AU) 2024-03-28 US claimed
EP-4291171-A1 METHOD OF PREPARING A TOPICAL PHARMACEUTICAL COMPOSITION Phebra Pty Ltd (AU) 2023-12-20 EP claimed
US-20170348303-A1 PHARMACEUTICAL COMPOSITIONS CHARLESTON LABORATORIES, INC. 2017-12-07 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20140030322-A1 PHARMACEUTICAL COMPOSITIONS LOCL PHARMA, INC. 2014-01-30 US claimed
US-20120201888-A1 Pharmaceutical Compositions CHARLESTON LABORATORIES, INC. (US) 2012-08-09 US claimed
EP-2240022-A2 PHARMACEUTICAL COMPOSITIONS Charleston Laboratories, Inc. (US) 2010-10-20 EP claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
US-20100172916-A1 SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS AUSPEX PHARMACEUTICALS, INC. (US) 2010-07-08 US claimed
WO-2010054286-A2 SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS AUSPEX PHARMACEUTICALS, INC. (US) 2010-05-14 WO claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
EP-1861003-A1 A METHOD AND A SYSTEM FOR ASSESSING NEUROLOGICAL CONDITIONS Mentis Cura ehf. (IS) 2007-12-05 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
WO-2006094797-A1 A METHOD AND A SYSTEM FOR ASSESSING NEUROLOGICAL CONDITIONS MENTIS CURA EHF. (IS) 2006-09-14 WO claimed
US-20050152957-A1 Compositions and delivery systems for administration of a local anesthetic agent CORIUM INTERNATIONAL (US) 2005-07-14 US claimed
US-20030027833-A1 Compositions and delivery systems for administration of a local anesthetic agent CORIUM INTERNATIONAL, INC. 2003-02-06 US claimed
WO-2002089849-A1 COMPOSITIONS AND DELIVERY SYSTEMS FOR ADMINISTRATION OF A LOCAL ANESTHETIC AGENT CORIUM INTERNATIONAL (US) 2002-11-14 WO claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100172916-A1 SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS MC1R, TYR, MITF ALDH1A1 554/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.