Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATP4A | P20648 | 2/20 | 0.39 |
| ▸ | ATP4B | P51164 | 2/20 | 0.39 |
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.39 |
| ▸ | GUCY1A2 | P33402 | 3/20 | 0.39 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014335 | 0.85 | MEN1 (0.43) | PTGER1SGMS2PSEN1PSEN2APH1B | |
| SCHEMBL7012019 | 0.78 | PLA2G1B (0.38) | PTGER1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7013513 | 0.78 | SGMS2 (0.43) | PTGER1SGMS2PSEN1PSEN2APH1B | |
| SCHEMBL7011107 | 0.78 | SGMS2 (0.43) | PTGER1SGMS2PSEN1PSEN2APH1B | |
| SCHEMBL7009138 | 0.76 | ALDH1A1 (0.42) | PTGER1SGMS2PSEN1PSEN2APH1B | |
| SCHEMBL7006126 | 0.74 | PLA2G1B (0.46) | SGMS2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7017573 | 0.73 | MEN1 (0.42) | PTGER1SGMS2PSEN1PSEN2APH1B | |
| SCHEMBL7011801 | 0.73 | PLA2G1B (0.45) | SGMS2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7013814 | 0.72 | ATP4A (0.42) | PTGER1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7010603 | 0.71 | MRGPRX4 (0.42) | PTGER1SGMS2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |