Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1025290 | 0.87 | SMN1; SMN2 (0.42) | NPC1L3MBTL1GAARAB9ASMN1; SMN2 | |
| SCHEMBL1025289 | 0.87 | SMN1; SMN2 (0.42) | NPC1L3MBTL1GAARAB9ASMN1; SMN2 | |
| SCHEMBL2915566 | 0.82 | NPC1 (1.00) | NPC1L3MBTL1GAARAB9ASMN1; SMN2 | |
| SCHEMBL18240065 | 0.82 | NPC1 (1.00) | NPC1L3MBTL1GAARAB9ASMN1; SMN2 | |
| SCHEMBL1389297 | 0.82 | NPC1 (1.00) | NPC1L3MBTL1GAARAB9ASMN1; SMN2 | |
| SCHEMBL30538675 | 0.82 | NPC1 (1.00) | NPC1L3MBTL1GAARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11748662 | 0.79 | NPC1 (0.94) | NPC1L3MBTL1GAARAB9ASMN1; SMN2 | |
| SCHEMBL25504 | 0.77 | — | — | |
| SCHEMBL5803236 | 0.77 | ALDH1A1 (0.52) | NPC1L3MBTL1RAB9ASMN1; SMN2CYP3A4 | |
| SCHEMBL11471806 | 0.77 | ALDH1A1 (0.52) | NPC1L3MBTL1RAB9ASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019528-B1 | METHOD FOR ASSAYING PROTEOLYTIC ENZYMES USING FLUORESCENCE-QUENCHED SUBSTRATES | TNO (NL) | 2003-10-29 | — | — | EP | claimed |
| US-6127139-A | INCUBATING SAMPLE WITH AN IMMOBILIZED SUBSTRATE, OPTIONALLY SEPARATING THE LIQUID FROM THE CARRIER, IRRADIATING CARRIER AND MEASURING FLUORESCENCE | NEDERLANDS ORGANISATLE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK (TNO) (NL) | 2000-10-03 | — | — | US | claimed |
| EP-1019528-A1 | METHOD FOR ASSAYING PROTEOLYTIC ENZYMES USING FLUORESCENCE-QUENCHED SUBSTRATES | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2000-07-19 | — | — | EP | claimed |
| WO-1997025437-A1 | METHOD FOR ASSAYING PROTEOLYTIC ENZYMES USING FLUORESCENCE-QUENCHED SUBSTRATES | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 1997-07-17 | — | — | WO | claimed |
| EP-1019528-B1 | METHOD FOR ASSAYING PROTEOLYTIC ENZYMES USING FLUORESCENCE-QUENCHED SUBSTRATES | TNO (NL) | 2003-10-29 | — | — | EP | disclosed |
| US-6127139-A | INCUBATING SAMPLE WITH AN IMMOBILIZED SUBSTRATE, OPTIONALLY SEPARATING THE LIQUID FROM THE CARRIER, IRRADIATING CARRIER AND MEASURING FLUORESCENCE | NEDERLANDS ORGANISATLE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK (TNO) (NL) | 2000-10-03 | — | — | US | disclosed |
| EP-1019528-A1 | METHOD FOR ASSAYING PROTEOLYTIC ENZYMES USING FLUORESCENCE-QUENCHED SUBSTRATES | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2000-07-19 | — | — | EP | disclosed |
| WO-1997025437-A1 | METHOD FOR ASSAYING PROTEOLYTIC ENZYMES USING FLUORESCENCE-QUENCHED SUBSTRATES | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 1997-07-17 | — | — | WO | disclosed |