Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11625039 | 0.84 | KDM4E (0.45) | ALDH1A1MAPTKDM4ENPSR1KMT2A | |
| SCHEMBL7147721 | 0.81 | GAA (0.46) | ALDH1A1MAPTKDM4EPKMJAK2 | |
| SCHEMBL512553 | 0.79 | NPSR1 (0.58) | ALDH1A1MAPTKDM4EPKMNPSR1 | |
| SCHEMBL12143535 | 0.77 | L3MBTL1 (0.46) | ALDH1A1MAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL4742052 | 0.76 | MAPK1 (0.47) | ALDH1A1KDM4EPKMNPSR1MAPK1 | |
| SCHEMBL9382400 | 0.76 | KMT2A (0.45) | ALDH1A1MAPTKDM4EPKMJAK2 | |
| SCHEMBL5115571 | 0.76 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4EPKMJAK2 | |
| SCHEMBL12142140 | 0.76 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4EPKMJAK2 | |
| SCHEMBL5108684 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EPKMLMNAHTT | |
| SCHEMBL9381697 | 0.76 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4EPKMJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808313-B1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | disclosed |
| US-5919788-A | PSYCHOLOGICAL DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-07-06 | — | — | US | disclosed |
| EP-0808313-A1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996023784-A1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-08-08 | — | — | WO | disclosed |
| EP-0378254-B1 | 2-Aminopyrimidinone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1994-06-22 | — | — | EP | disclosed |
| EP-0378255-B1 | 2-Aminopyrimidinone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1994-04-27 | — | — | EP | disclosed |
| US-5284854-A | Antiserotonin. antihistamine agents; for sleep disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-02-08 | — | — | US | disclosed |
| US-5256659-A | Antiserotonine agents, antihistamines for nervous system disorders or psychological disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-10-26 | — | — | US | disclosed |
| US-5140029-A | Administering for nervous system, sleep or psychotic disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-18 | — | — | US | disclosed |
| US-5008268-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-16 | — | — | US | disclosed |