Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7147721 | 0.79 | GAA (0.46) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL7146938 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTKDM4EMAPK1KMT2A | |
| SCHEMBL512553 | 0.76 | NPSR1 (0.58) | ALDH1A1MAPTKDM4EMAPK1KMT2A | |
| SCHEMBL12143535 | 0.75 | L3MBTL1 (0.46) | ALDH1A1MAPTKDM4EMAPK1KMT2A | |
| SCHEMBL9381697 | 0.73 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4EMAPK1KMT2A | |
| SCHEMBL12142140 | 0.73 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4EMAPK1PKM | |
| SCHEMBL9382400 | 0.73 | KMT2A (0.45) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL5108684 | 0.73 | KDM4E (0.58) | ALDH1A1KDM4EPKMCYP2C9CYP2C19 | |
| SCHEMBL15427232 | 0.73 | XDH (0.38) | KDM4EKMT2AHCAR2 | |
| SCHEMBL7149943 | 0.71 | ALDH1A1 (0.55) | ALDH1A1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371769-B2 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-05-13 | — | — | US | disclosed |
| EP-1828168-A2 | TETRAHYDROPYRIDIN-4-YL INDOLES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | Solvay Pharmaceuticals B.V. (NL) | 2007-09-05 | — | — | EP | disclosed |
| US-20070066634-A2 | TETRAHYDROPYRIDIN-4-YL INDOLES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | SOLVAY PHARMECEUTICALS B.V. (NL) | 2007-03-22 | — | — | US | disclosed |
| WO-2006061373-A2 | TETRAHYDROPYRIDIN-4-YL INDOLES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-06-15 | — | — | WO | disclosed |
| US-20060122206-A1 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARMACEUTICALS B.V. | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122206-A1 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SLC6A3, HTR3C, DRD3 | ALDH1A1 1366/4885MAPT 1253/4885KDM4E 4257/4885 |
| US-20070066634-A2 | TETRAHYDROPYRIDIN-4-YL INDOLES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | SLC6A3, HTR3C, DRD3 | ALDH1A1 1366/4885MAPT 1253/4885KDM4E 4257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.