Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411615 | 1.00 | HTR7 (0.37) | HTR7RAB9ATDP1HRH2HRH1 | |
| SCHEMBL5401313 | 0.87 | RAB9A (0.39) | RAB9ATDP1KMT2AMAPTSLC18A3 | |
| SCHEMBL5420138 | 0.84 | HTRA1 (0.41) | RAB9ATDP1KMT2AMAPTSLC18A3 | |
| SCHEMBL5420141 | 0.84 | HTRA1 (0.41) | RAB9ATDP1KMT2AMAPTSLC18A3 | |
| SCHEMBL5421519 | 0.84 | HTRA1 (0.36) | KMT2AALDH1A1CHRM2CHRM1HTRA1 | |
| SCHEMBL5401106 | 0.84 | SIGMAR1 (0.39) | KMT2AALDH1A1CHRM2CHRM1HTRA1 | |
| SCHEMBL5404264 | 0.80 | ECE1 (0.35) | HRH2HRH1KMT2AALDH1A1CHRM2 | |
| SCHEMBL5398886 | 0.80 | CHRM2 (0.36) | KMT2AALDH1A1CHRM2CHRM1HTRA1 | |
| SCHEMBL5409681 | 0.80 | RAB9A (0.40) | RAB9ATDP1SLC18A3DRD2 | |
| SCHEMBL5409672 | 0.80 | RAB9A (0.40) | RAB9ATDP1SLC18A3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |