Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358496 | 1.00 | TSHR (0.39) | TSHRMAPTALDH1A1ITGA4KMT2A | |
| SCHEMBL7145020 | 0.86 | MAPT (0.41) | TSHRMAPTALDH1A1ITGA4KMT2A | |
| SCHEMBL9616757 | 0.74 | ADORA3 (0.41) | TSHRMAPTALDH1A1KMT2ANPSR1 | |
| SCHEMBL329169 | 0.72 | KMT2A (0.40) | TSHRMAPTKMT2ANPSR1POLB | |
| SCHEMBL5862723 | 0.72 | KMT2A (0.40) | TSHRMAPTKMT2ANPSR1POLB | |
| SCHEMBL5860484 | 0.72 | KMT2A (0.40) | TSHRMAPTKMT2ANPSR1POLB | |
| SCHEMBL14968052 | 0.70 | HTT (0.45) | MAPTALDH1A1KMT2ANPSR1POLB | |
| SCHEMBL28476445 | 0.69 | KDM1A (0.36) | TSHRMAPTALDH1A1KMT2ANPSR1 | |
| SCHEMBL13059640 | 0.69 | POLB (0.37) | TSHRMAPTKMT2ANPSR1POLB | |
| SCHEMBL6580824 | 0.68 | EPHX1 (0.36) | KMT2ANPSR1POLBEPHX1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521445-B1 | Stereoselective ester hydrolysis of racemic trans-3-(4-methoxyphenyl) glycidic acid ester using a hydrolase enzyme; resolution; diltiazem production | SEPRACOR, INC. | 2003-02-18 | — | — | US | disclosed |
| US-5274300-A | Patent withdrawn after O.G. published | SEPRACOR, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0440723-A4 | PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS | — | 1992-05-20 | — | — | EP | disclosed |
| EP-0440723-A1 | PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS. | SEPRACOR INC (US) | 1991-08-14 | — | — | EP | disclosed |
| WO-1990004643-A1 | PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS | SEPRACOR, INC. (US) | 1990-05-03 | — | — | WO | disclosed |