Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358496 | 0.86 | TSHR (0.39) | MAPTALDH1A1ITGA4POLBKMT2A | |
| SCHEMBL7147343 | 0.86 | TSHR (0.39) | MAPTALDH1A1ITGA4POLBKMT2A | |
| SCHEMBL9616757 | 0.84 | ADORA3 (0.41) | MAPTHTTALDH1A1POLBKMT2A | |
| SCHEMBL14968052 | 0.78 | HTT (0.45) | MAPTHTTALDH1A1POLBKMT2A | |
| SCHEMBL14968177 | 0.75 | CYP3A4 (0.51) | MAPTHTTALDH1A1ITGA4POLB | |
| SCHEMBL11435892 | 0.74 | NPSR1 (0.44) | MAPTHTTALDH1A1ITGA4POLB | |
| SCHEMBL14968287 | 0.74 | MAPT (0.41) | MAPTHTTALDH1A1POLBKMT2A | |
| SCHEMBL16110034 | 0.68 | CYP3A4 (0.44) | HTTKMT2AMEN1CYP3A4ALOX15 | |
| SCHEMBL28476445 | 0.67 | KDM1A (0.36) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL14967770 | 0.67 | CYP3A4 (0.44) | MAPTHTTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521445-B1 | Stereoselective ester hydrolysis of racemic trans-3-(4-methoxyphenyl) glycidic acid ester using a hydrolase enzyme; resolution; diltiazem production | SEPRACOR, INC. | 2003-02-18 | — | — | US | disclosed |
| EP-0657544-B1 | Process for preparing optically active glycidate esters | SEPRACOR INC (US) | 1997-12-29 | — | — | EP | disclosed |
| EP-0440723-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS | SEPRACOR INC (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0657544-A1 | Process for preparing optically active glycidate esters | SEPRACOR, INC. (US) | 1995-06-14 | — | — | EP | disclosed |
| US-5274300-A | Patent withdrawn after O.G. published | SEPRACOR, INC. (US) | 1993-12-28 | — | — | US | disclosed |