Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10810948 | 0.84 | GSK3B (0.52) | GSK3BPTPN1AKR1C3MEN1KMT2A | |
| SCHEMBL28050059 | 0.82 | GSK3B (0.55) | GSK3BPTPN1AKR1C3MEN1KMT2A | |
| Bromide SCHEMBL10751253 | 0.82 | GSK3B (0.50) | GSK3BPTPN1AKR1C3MEN1KMT2A | |
| SCHEMBL9409741 | 0.82 | GSK3B (0.70) | GSK3BPTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL5628492 | 0.81 | HDAC3 (0.57) | MEN1KMT2A | |
| SCHEMBL7113447 | 0.81 | GSK3B (0.53) | GSK3BPTPN1AKR1C3MEN1KMT2A | |
| SCHEMBL6189469 | 0.80 | KCNK3 (0.69) | GSK3BPTPN1MEN1KMT2AKCNK3 | |
| SCHEMBL1120803 | 0.78 | ALDH1A1 (0.67) | GSK3BPTPN1 | |
| SCHEMBL8924324 | 0.78 | KMT2A (0.48) | GSK3BPTPN1MEN1KMT2AKCNK3 | |
| SCHEMBL3798840 | 0.77 | NPSR1 (0.69) | GSK3BPTPN1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882707-B1 | NOVEL TRICYCLIC COMPOUNDS AND DRUG COMPOSITIONS CONTAINING THE SAME | ASAHI CHEMICAL IND (JP) | 2003-10-08 | — | — | EP | disclosed |
| US-6545053-B1 | Aminoethoxyfluorene derivatives are beta-3 adrenaline receptor agonists and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc. | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2003-04-08 | — | — | US | disclosed |
| US-6187809-B1 | BETA-3 ADRENALINE RECEPTOR AGONIST DRUGS FOR THE TREATMENT OF DIABETES, OBESITY, AND HYPERLIPEMIA; 2-(N-(2-(DIBENZOFURAN-3-YLOXY)ETHYL)AMINO)-1-PHENYLETHANOL, FOR EXAMPLE | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0882707-A1 | NOVEL TRICYCLIC COMPOUNDS AND DRUG COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1998-12-09 | — | — | EP | disclosed |