Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 7/20 | 0.69 |
| ▸ | KCNK9 | Q9NPC2 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28050059 | 0.87 | GSK3B (0.55) | KCNK3KCNK9KMT2AMEN1TP53 | |
| SCHEMBL6346822 | 0.85 | KCNK3 (0.71) | KCNK3KCNK9KMT2AMEN1TP53 | |
| SCHEMBL8980369 | 0.84 | KCNK3 (0.69) | KCNK3KCNK9KMT2AMEN1TP53 | |
| SCHEMBL3066613 | 0.83 | KMT2A (0.66) | KMT2AMEN1SIRT1RAB9ANPC1 | |
| SCHEMBL2298254 | 0.82 | KCNK3 (1.00) | KCNK3KCNK9KMT2AMEN1TP53 | |
| SCHEMBL5628492 | 0.82 | HDAC3 (0.57) | KMT2AMEN1TP53RAB9ANPC1 | |
| SCHEMBL679144 | 0.81 | KMT2A (0.90) | KCNK3KCNK9KMT2AMEN1TP53 | |
| Hydrochloric Acid SCHEMBL2106175 | 0.80 | KMT2A (0.87) | KCNK3KCNK9KMT2AMEN1TP53 | |
| SCHEMBL7500312 | 0.80 | KMT2A (0.84) | KCNK3KCNK9KMT2AMEN1SIRT1 | |
| SCHEMBL7745302 | 0.80 | KCNK3 (0.79) | KCNK3KCNK9KMT2AMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181283-B1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMA (US) | 2005-02-02 | — | — | EP | disclosed |
| US-6620828-B2 | Antiproliferative agents | AGOURON PHARMACEUTICALS, INC. | 2003-09-16 | — | — | US | disclosed |
| US-20020025976-A1 | Thiazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2002-02-28 | — | — | US | disclosed |
| EP-1181283-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075120-A1 | DIAMINOTHIAZOLES AND THEIR USE FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020025976-A1 | Thiazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use | BRAF, CDK2, CHUK | KCNK3 3133/4885KCNK9 3992/4885KMT2A 4434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.