Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
| ▸ | SHBG | P04278 | 4/20 | 0.64 |
| ▸ | STS | P08842 | 4/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | PGR | P06401 | 3/20 | 0.64 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.64 |
| ▸ | AR | P10275 | 3/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.64 |
| ▸ | SNCA | P37840 | 3/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5675177 | 1.00 | ESR1 (0.64) | ESR1ESR2LMNAHSD17B10SHBG | |
| SCHEMBL8623796 | 0.87 | LMNA (0.67) | ESR1ESR2LMNAHSD17B10SHBG | |
| SCHEMBL6871662 | 0.82 | STS (0.69) | ESR1ESR2LMNAHSD17B10STS | |
| SCHEMBL7097126 | 0.82 | ABCC1 (0.48) | ESR1ESR2LMNAHSD17B10SHBG | |
| SCHEMBL6636478 | 0.82 | ABCC1 (0.48) | ESR1ESR2LMNAHSD17B10SHBG | |
| SCHEMBL8778685 | 0.82 | ESR1 (0.44) | ESR1ESR2LMNAHSD17B10SHBG | |
| SCHEMBL7100301 | 0.82 | ABCC1 (0.47) | ESR1ESR2LMNAHSD17B10SHBG | |
| SCHEMBL1978822 | 0.81 | CYP2D6 (0.72) | ESR1ESR2LMNAHSD17B10SHBG | |
| SCHEMBL1978824 | 0.81 | CYP2D6 (0.72) | ESR1ESR2LMNAHSD17B10SHBG | |
| SCHEMBL7148062 | 0.81 | ABCC4 (0.55) | ESR1ESR2LMNAHSD17B10SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172056-B1 | ADMINISTERING A ESTROGEN COMPOUND | JENAPHARM GMBH & CO. KG (DE) | 2001-01-09 | — | — | US | claimed |
| EP-0707593-B1 | ORALLY ADMINISTERABLE ESTERS OF 14 ALPHA,15 ALPHA-METHYLENE-OESTRADIOL WITH AN OESTROGENIC ACTION | JENAPHARM GMBH (DE) | 1997-12-29 | — | — | EP | claimed |
| EP-1273590-A2 | Estra- 1,3,5(10)-triene Derivatives, Methods of Preparing Such Compounds and Pharmaceutical Compositions Containing Them | Jenapharm GmbH & Co. KG (DE) | 2003-01-08 | — | — | EP | disclosed |
| US-6172056-B1 | ADMINISTERING A ESTROGEN COMPOUND | JENAPHARM GMBH & CO. KG (DE) | 2001-01-09 | — | — | US | disclosed |
| US-6172056-B1 | ADMINISTERING A ESTROGEN COMPOUND | JENAPHARM GMBH & CO. KG (DE) | 2001-01-09 | — | — | US | disclosed |
| EP-0707593-B1 | ORALLY ADMINISTERABLE ESTERS OF 14 ALPHA,15 ALPHA-METHYLENE-OESTRADIOL WITH AN OESTROGENIC ACTION | JENAPHARM GMBH (DE) | 1997-12-29 | — | — | EP | disclosed |
| EP-0775155-A1 | ESTRA-1,3,5(10)-TRIENE DERIVATIVES, METHODS OF PREPARING SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Jenapharm GmbH & Co. KG (DE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005216-A1 | ESTRA-1,3,5(10)-TRIENE DERIVATIVES, METHODS OF PREPARING SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JENAPHARM GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |