Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654539 | 0.85 | LTB4R (0.40) | LTB4RMAP4K4ADORA1NR1I3FFAR1 | |
| SCHEMBL5656213 | 0.75 | LTB4R (0.42) | LTB4RCNR2AURKAAURKBADORA1 | |
| SCHEMBL12590510 | 0.73 | FNTA (0.40) | FNTAFNTB | |
| SCHEMBL12590507 | 0.72 | FNTA (0.43) | FNTAFNTB | |
| SCHEMBL1757804 | 0.71 | MEN1 (0.54) | LTB4RAURKAAURKBADORA1MEN1 | |
| SCHEMBL6010423 | 0.70 | LTB4R (0.38) | LTB4RCNR2AURKAAURKBNR1I3 | |
| SCHEMBL7166191 | 0.70 | RORC (0.42) | FNTAFNTB | |
| SCHEMBL5545656 | 0.68 | LTB4R (0.38) | LTB4RCNR2AURKAAURKBNR1I3 | |
| SCHEMBL5657044 | 0.67 | AURKA (0.35) | LTB4RCNR2AURKAAURKBNR1I3 | |
| SCHEMBL6009561 | 0.67 | FNTA (0.49) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322636-A1 | FARNESYL TRANSFERASE INHIBITING 6- (SUBSTITUTED PHENYL)METHYL]-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024683-A1 | FARNESYL TRANSFERASE INHIBITING 6-[(SUBSTITUTED PHENYL)METHYL]-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |