SCHEMBL7147640

SCHEMBL7147640

CCCCCC(C)(C)c1cc(-n2nc3ccc(C(=O)Cl)cc3n2)c(O)c(C(C)(C)c2ccccc2)c1

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 11/20 0.33
CNR2 P34972 10/20 0.33
GPR18 Q14330 3/20 0.33
GPR55 Q9Y2T6 3/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SCN5A Q14524 3/20 0.31
SCN9A Q15858 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7143518 0.93 CNR2 (0.39) CNR1CNR2GPR18GPR55HSP90AA1
SCHEMBL5668740 0.90 CNR2 (0.41) CNR1CNR2GPR18GPR55NPC1
SCHEMBL224924 0.88 CNR1 (0.38) CNR1CNR2GPR18GPR55NPC1
SCHEMBL769153 0.87 CNR1 (0.36) CNR1CNR2GPR18GPR55NPC1
SCHEMBL7147637 0.87 NPC1 (0.33) NPC1RAB9A
SCHEMBL10484223 0.87 CNR2 (0.37) CNR1CNR2GPR18GPR55NPC1
SCHEMBL7787052 0.86 CNR1 (0.34) CNR1CNR2GPR18GPR55NPC1
SCHEMBL5648044 0.86 CNR2 (0.36) CNR1CNR2GPR18GPR55NPC1
SCHEMBL5834169 0.85 CNR1 (0.37) CNR1CNR2GPR18GPR55NPC1
SCHEMBL5648165 0.85 CNR2 (0.37) CNR1CNR2GPR18GPR55NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6515051-B2 Stability and durability and a low loss rate when incorporated into automotive coatings; soluble in a variety of substrates including thermoplastic polymers and often are colorless CIBA SPECIALTY CHEMICALS CORPORATION 2003-02-04 US disclosed
US-6458872-B1 FOR USE IN AUTOMOTIVE COATINGS, THERMOPLASTIC FORMULATIONS CIBA SPECIALTY CHEMICALS CORPORATION 2002-10-01 US disclosed
US-20020099221-A1 Benzotriazole UV absorbers having enhanced durability RAVICHANDRAN RAMANATHAN (US) 2002-07-25 US disclosed
US-20020065341-A1 Benzotriazole UV absorbers having enhanced durability RAVICHANDRAN RAMANATHAN (US) 2002-05-30 US disclosed
US-6262151-B1 FOR AUTOMOTIVE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-17 US disclosed
US-20010007886-A1 Benzotriazole UV absorbers having enhanced durability RAVICHANDRAN RAMANATHAN (US) 2001-07-12 US disclosed
US-6166218-A Benzotriazole UV absorbers having enhanced durability CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-12-26 US disclosed
US-5977219-A Benzotriazole UV absorbers having enhanced durability CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020099221-A1 Benzotriazole UV absorbers having enhanced durability TERT, AHR, ARNT CNR1 2980/4885CNR2 2562/4885GPR18 2527/4885
US-20020065341-A1 Benzotriazole UV absorbers having enhanced durability TERT, AHR, ARNT CNR1 2980/4885CNR2 2562/4885GPR18 2527/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.