Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.55 |
| ▸ | CNR2 | P34972 | 2/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 9/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 9/20 | 0.51 |
| ▸ | TAS1R2 | Q8TE23 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6515896 | 0.81 | MTNR1A (0.43) | LMNA | |
| SCHEMBL6520141 | 0.73 | CNR1 (0.75) | CNR1CNR2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3395117 | 0.73 | CNR1 (0.75) | CNR1CNR2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL12521450 | 0.69 | TAS1R3 (0.74) | TAS1R3TAS1R1TAS1R2ALDH1A1HTT | |
| SCHEMBL1150791 | 0.69 | GFER (0.43) | ALDH1A1HSD17B10 | |
| SCHEMBL22867848 | 0.69 | HSD17B2 (0.73) | TAS1R3TAS1R1TAS1R2ALDH1A1HTT | |
| SCHEMBL17743126 | 0.69 | KDM4E (0.55) | CNR1CNR2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL17743219 | 0.69 | KDM4E (0.52) | CNR1CNR2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL606392 | 0.68 | HTT (0.63) | TAS1R3TAS1R1TAS1R2ALDH1A1HTT | |
| SCHEMBL15006999 | 0.68 | HTT (0.63) | TAS1R3TAS1R1TAS1R2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370530-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | Aventis Pharma Deutschland GmbH (DE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002064565-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-22 | — | — | WO | disclosed |