Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.48 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28289469 | 0.77 | ENPP3 (0.59) | AOC3ENPP3ENPP1PDE4BPDE4D | |
| SCHEMBL6996945 | 0.76 | ENPP3 (0.60) | ENPP3ENPP1 | |
| SCHEMBL5310580 | 0.73 | ACHE (0.56) | AOC3ENPP3ENPP1HDAC1HDAC8 | |
| SCHEMBL6328562 | 0.73 | AOC3 (0.61) | AOC3ENPP3ENPP1 | |
| SCHEMBL8836113 | 0.73 | HDAC1 (0.53) | AOC3ENPP3ENPP1PDE4BHDAC1 | |
| SCHEMBL2056110 | 0.72 | SCN10A (0.54) | AOC3ENPP3ENPP1PDE4BNOTUM | |
| SCHEMBL3085910 | 0.70 | PDE4B (0.51) | AOC3ENPP3ENPP1PDE4BHDAC1 | |
| SCHEMBL6639205 | 0.70 | HDAC1 (0.51) | AOC3ENPP3ENPP1PDE4BHDAC1 | |
| SCHEMBL5540418 | 0.70 | PDE4B (0.50) | AOC3PDE4BHDAC1HDAC8HDAC6 | |
| SCHEMBL2056286 | 0.70 | PDE4B (0.50) | AOC3PDE4BHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326861-A1 | ALPHA-ARYL ETHANOLAMINES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS | Pfizer Products Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032897-A1 | ALPHA-ARYL ETHANOLAMINES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2002-04-25 | — | — | WO | disclosed |