Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.67 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | CDK1 | P06493 | 1/20 | 0.67 |
| ▸ | LYN | P07948 | 1/20 | 0.67 |
| ▸ | PIM1 | P11309 | 1/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.67 |
| ▸ | PRKACA | P17612 | 1/20 | 0.67 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.67 |
| ▸ | CDK2 | P24941 | 1/20 | 0.67 |
| ▸ | MARK3 | P27448 | 1/20 | 0.67 |
| ▸ | GSK3B | P49841 | 1/20 | 0.67 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.67 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.67 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.67 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.67 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.67 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8119122 | 0.84 | TGFBR1 (0.48) | AKT1RPS6KA3AURKACDK1LYN | |
| SCHEMBL6132035 | 0.83 | TGFBR1 (0.61) | AKT1RPS6KA3AURKACDK1LYN | |
| SCHEMBL8111644 | 0.82 | TGFBR1 (0.46) | AKT1RPS6KA3AURKACDK1LYN | |
| SCHEMBL14519516 | 0.82 | EGFR (0.63) | AKT1RPS6KA3AURKACDK1LYN | |
| SCHEMBL6132075 | 0.81 | MAPK14 (0.71) | AKT1RPS6KA3AURKACDK1LYN | |
| SCHEMBL6076343 | 0.80 | RPS6KA3 (1.00) | AKT1RPS6KA3AURKACDK1LYN | |
| SCHEMBL6073381 | 0.80 | RPS6KA3 (1.00) | AKT1RPS6KA3AURKACDK1LYN | |
| SCHEMBL14336014 | 0.76 | RPS6KA3 (0.58) | AKT1RPS6KA3AURKACDK1LYN | |
| SCHEMBL19302646 | 0.75 | AKT2 (0.68) | AKT1RPS6KA3AURKACDK1LYN | |
| SCHEMBL91416 | 0.74 | RAB9A (0.59) | MAPK14CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525059-B1 | Mitogen-activated protein kinases (MAP); | G. D. SEARLE & COMPANY | 2003-02-25 | — | — | US | disclosed |