Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 4/20 | 1.00 |
| ▸ | AKT1 | P31749 | 2/20 | 1.00 |
| ▸ | AURKA | O14965 | 1/20 | 1.00 |
| ▸ | CDK1 | P06493 | 1/20 | 1.00 |
| ▸ | LYN | P07948 | 1/20 | 1.00 |
| ▸ | PIM1 | P11309 | 1/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 1/20 | 1.00 |
| ▸ | PRKACA | P17612 | 1/20 | 1.00 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 1.00 |
| ▸ | CDK2 | P24941 | 1/20 | 1.00 |
| ▸ | MARK3 | P27448 | 1/20 | 1.00 |
| ▸ | GSK3B | P49841 | 1/20 | 1.00 |
| ▸ | PRKCZ | Q05513 | 1/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 1/20 | 1.00 |
| ▸ | ERBB4 | Q15303 | 1/20 | 1.00 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 1.00 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 1.00 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6076343 | 1.00 | RPS6KA3 (1.00) | RPS6KA3AKT1AURKACDK1LYN | |
| SCHEMBL5248907 | 0.90 | RPS6KA3 (0.81) | RPS6KA3AKT1AURKACDK1LYN | |
| Bromide SCHEMBL11756541 | 0.88 | RPS6KA3 (0.79) | RPS6KA3AKT1AURKACDK1LYN | |
| SCHEMBL6132075 | 0.82 | MAPK14 (0.71) | RPS6KA3AKT1AURKACDK1LYN | |
| SCHEMBL5252677 | 0.82 | MAPK14 (1.00) | RPS6KA3AKT1AURKACDK1LYN | |
| SCHEMBL5252213 | 0.82 | MAPK14 (0.71) | RPS6KA3AKT1AURKACDK1LYN | |
| SCHEMBL7148388 | 0.80 | AKT1 (0.67) | RPS6KA3AKT1AURKACDK1LYN | |
| SCHEMBL6132062 | 0.80 | RPS6KA3 (0.70) | RPS6KA3AKT1AURKACDK1LYN | |
| SCHEMBL14519450 | 0.80 | RPS6KA3 (0.66) | RPS6KA3AKT1AURKACDK1LYN | |
| Propionic Acid SCHEMBL10557736 | 0.76 | RPS6KA3 (0.64) | RPS6KA3AKT1AURKACDK1LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136823-A1 | HETEROCYCLIC CONTAINING AMINES AS KINASE B INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |
| US-20050159444-A1 | Bicyclic unsaturated tertiary amine compounds | SANKYO COMPANY, LIMITED (JP) | 2005-07-21 | — | — | US | disclosed |
| EP-1541571-A1 | BICYCLIC UNSATURATED TERTIARY AMINE COMPOUND | Sankyo Company, Limited (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159444-A1 | Bicyclic unsaturated tertiary amine compounds | IL1B, IL1A, STAT6 | RPS6KA3 807/4885AKT1 1119/4885AURKA 1867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.