Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941601 | 0.88 | OPRM1 (0.51) | L3MBTL1KCNH2BRD4OPRM1OPRD1 | |
| SCHEMBL15202975 | 0.87 | KCNH2 (0.69) | L3MBTL1KCNH2KMT2AKDM4EBRD4 | |
| SCHEMBL2707784 | 0.84 | GPR119 (0.52) | KDM4EOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5871239 | 0.82 | OPRM1 (0.54) | GAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7290423 | 0.81 | KCNH2 (0.63) | L3MBTL1KCNH2 | |
| SCHEMBL3940080 | 0.81 | OPRM1 (0.46) | KCNH2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL2675232 | 0.81 | OPRM1 (0.52) | GAAALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL15785122 | 0.80 | KCNH2 (0.56) | L3MBTL1KCNH2KMT2AKDM4EBRD4 | |
| SCHEMBL4675514 | 0.80 | PRMT5 (0.44) | L3MBTL1KMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL4675524 | 0.80 | PRMT5 (0.44) | L3MBTL1KMT2AKDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808313-B1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | disclosed |
| US-5919788-A | PSYCHOLOGICAL DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-07-06 | — | — | US | disclosed |
| EP-0808313-A1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996023784-A1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-08-08 | — | — | WO | disclosed |