Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 9/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940080 | 0.93 | OPRM1 (0.46) | OPRM1OPRD1OPRK1OPRL1PRMT5 | |
| SCHEMBL7149147 | 0.88 | L3MBTL1 (0.56) | OPRM1OPRD1OPRK1OPRL1L3MBTL1 | |
| SCHEMBL4675524 | 0.85 | PRMT5 (0.44) | OPRM1OPRD1OPRK1OPRL1PRMT5 | |
| SCHEMBL4675514 | 0.85 | PRMT5 (0.44) | OPRM1OPRD1OPRK1OPRL1PRMT5 | |
| SCHEMBL5197149 | 0.84 | GPR119 (0.41) | PRMT5WDR77L3MBTL1 | |
| SCHEMBL5197000 | 0.84 | DPP4 (0.43) | PRMT5WDR77 | |
| SCHEMBL5223968 | 0.83 | CHRM2 (0.49) | — | |
| SCHEMBL5199029 | 0.82 | NPSR1 (0.42) | PRMT5WDR77L3MBTL1DRD2BRD4 | |
| SCHEMBL2707784 | 0.80 | GPR119 (0.52) | OPRM1OPRD1OPRK1OPRL1PRMT5 | |
| SCHEMBL5196493 | 0.79 | GPR119 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016225-A1 | 1-PIPERIDINYL-6-PIPERIDINYLSULFONYLINDOLES AS 5-HT (2B) RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016227-A2 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-02-05 | — | — | WO | disclosed |