Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3999031 | 0.86 | ALDH1A1 (0.48) | MAPTHTTALDH1A1CA12CA2 | |
| SCHEMBL2044616 | 0.86 | ALDH1A1 (0.48) | MAPTHTTALDH1A1CA12CA2 | |
| SCHEMBL27913110 | 0.86 | TSHR (0.44) | MAPTHTTALDH1A1CA12CA2 | |
| SCHEMBL13064827 | 0.84 | CA12 (0.50) | MAPTALDH1A1CA12CA7CA9 | |
| SCHEMBL13764875 | 0.83 | MMP1 (0.47) | MAPTHTTALDH1A1CA12CA2 | |
| SCHEMBL27788468 | 0.82 | TBXA2R (0.51) | HTTALDH1A1FOLH1LMNACACNA1B | |
| SCHEMBL29117963 | 0.82 | HTT (0.45) | MAPTHTTALDH1A1CA12CA2 | |
| SCHEMBL12268175 | 0.80 | ALDH1A1 (0.59) | MAPTHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL12744760 | 0.80 | ALDH1A1 (0.59) | MAPTHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL17451233 | 0.80 | ALDH1A1 (0.59) | MAPTHTTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552223-B1 | Metalloproteinase enzyme inhibitors | ASTRAZENECA AB (SE) | 2003-04-22 | — | — | US | disclosed |
| EP-1109777-A1 | N-HYDROXYACYLAMINO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AstraZeneca AB (SE) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012467-A1 | N-HYDROXYACYLAMINO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |