SCHEMBL7149348

SCHEMBL7149348

c1ccc(Nc2ccc(NCCCCNc3ccc(Nc4ccccc4)cc3)cc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.73
MAPT P10636 3/20 0.73
HSD17B10 Q99714 5/20 0.62
L3MBTL1 Q9Y468 4/20 0.62
ALOX12 P18054 3/20 0.62
TSHR P16473 3/20 0.62
TDP1 Q9NUW8 3/20 0.62
ALOX15 P16050 2/20 0.62
PTGS1 P23219 1/20 0.62
SLC6A2 P23975 1/20 0.62
MAPK1 P28482 1/20 0.62
PTGS2 P35354 1/20 0.62
HTR2B P41595 1/20 0.62
KCNH3 Q9ULD8 6/20 0.50
CYP3A4 P08684 4/20 0.50
HPGD P15428 2/20 0.50
HTT P42858 2/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18660199 0.98 ALDH1A1 (0.70) ALDH1A1MAPTHSD17B10L3MBTL1ALOX12
SCHEMBL19018359 0.98 ALDH1A1 (0.70) ALDH1A1MAPTHSD17B10L3MBTL1ALOX12
SCHEMBL18660198 0.98 ALDH1A1 (0.70) ALDH1A1MAPTHSD17B10L3MBTL1ALOX12
SCHEMBL18660177 0.98 ALDH1A1 (0.70) ALDH1A1MAPTHSD17B10L3MBTL1ALOX12
SCHEMBL19018136 0.90 ALDH1A1 (0.68) ALDH1A1MAPTHSD17B10L3MBTL1ALOX12
SCHEMBL4970157 0.90 ALDH1A1 (0.89) ALDH1A1MAPTHSD17B10L3MBTL1TDP1
SCHEMBL9579878 0.90 ALDH1A1 (0.59) ALDH1A1MAPTHSD17B10L3MBTL1ALOX12
SCHEMBL809502 0.90 KCNH3 (0.65) ALDH1A1MAPTHSD17B10L3MBTL1ALOX12
SCHEMBL809713 0.88 KCNH3 (0.63) ALDH1A1MAPTHSD17B10L3MBTL1ALOX12
SCHEMBL1851675 0.88 KCNH3 (0.63) ALDH1A1MAPTHSD17B10L3MBTL1ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1299073-A2 AGENTS FOR COLOURING KERATIN FIBRES, CONTAINING DERIVATIVES OF BENZO(B)FURANE-3-ONE AND/OR BENZO(B)THIOPHENE-3-ONE Henkel Kommanditgesellschaft auf Aktien (DE) 2003-04-09 EP disclosed
WO-2002000180-A2 AGENTS FOR COLOURING KERATIN FIBRES, CONTAINING DERIVATIVES OF BENZO[B]FURANE-3-ONE AND/OR BENZO[B]THIOPHENE-3-ONE HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-01-03 WO disclosed