Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14793428 | 0.84 | DRD2 (0.68) | DRD2HSD17B10KMT2AMEN1MAPT | |
| SCHEMBL1306444 | 0.83 | KCNH2 (0.65) | DRD2ADRB1MAPTALDH1A1KDM4E | |
| SCHEMBL24123590 | 0.81 | MAPT (0.51) | DRD2KMT2AMEN1ADRB1MAPT | |
| SCHEMBL29656856 | 0.80 | HTR3E (0.73) | DRD2HSD17B10KMT2AMEN1HTR3E | |
| SCHEMBL28599511 | 0.80 | HTR3E (0.73) | DRD2HSD17B10KMT2AMEN1HTR3E | |
| SCHEMBL8353109 | 0.80 | DRD2 (0.75) | DRD2HSD17B10KMT2AMEN1HTR3E | |
| SCHEMBL9670409 | 0.78 | DRD2 (0.68) | DRD2HSD17B10KMT2AMEN1HTR3E | |
| SCHEMBL21361433 | 0.78 | DRD2 (0.68) | DRD2HSD17B10KMT2AMEN1HTR3E | |
| SCHEMBL12789832 | 0.78 | DRD2 (0.68) | DRD2HSD17B10KMT2AMEN1HTR3E | |
| SCHEMBL6703230 | 0.78 | MAPT (0.61) | HSD17B10KMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054863-B1 | 2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY | DUPHAR INT RES (NL) | 2003-05-07 | — | — | EP | disclosed |
| US-6281216-B1 | 2-aminoquinoline derivatives having d4-agonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 2001-08-28 | — | — | US | disclosed |
| EP-1054863-A2 | 2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040068-A2 | 2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1999-08-12 | — | — | WO | disclosed |