Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773980 | 0.94 | AURKA (0.52) | AURKALRRK2KDRCDK1SYK | |
| SCHEMBL4763724 | 0.84 | CA2 (0.47) | AURKAKDRCDK1SYKCA2 | |
| SCHEMBL4774317 | 0.84 | AURKA (0.53) | AURKAKDRCDK1SYKCA2 | |
| SCHEMBL4768983 | 0.84 | AURKA (0.53) | AURKALRRK2KDRCDK1SYK | |
| SCHEMBL4766361 | 0.82 | AURKA (0.49) | AURKAKDRCDK1SYKCA2 | |
| SCHEMBL4763589 | 0.82 | AURKA (0.51) | AURKALRRK2KDRCDK1SYK | |
| SCHEMBL4772099 | 0.78 | CA2 (0.52) | AURKALRRK2KDRCDK1SYK | |
| SCHEMBL4772198 | 0.78 | AURKA (0.46) | AURKALRRK2KDRCDK1SYK | |
| SCHEMBL4768143 | 0.78 | SYK (0.53) | AURKAKDRCDK1SYKCA2 | |
| SCHEMBL4766554 | 0.78 | AURKA (0.46) | AURKALRRK2KDRCDK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-A1 | PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002004429-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |