Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | PNMT | P11086 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1467248 | 0.98 | KDM4E (0.68) | KDM4EATMTSHRCYP1A2CYP3A4 | |
| SCHEMBL6348746 | 0.89 | KDM4E (0.56) | KDM4EATMTSHRCYP1A2CYP3A4 | |
| SCHEMBL793618 | 0.85 | KDM4E (0.70) | KDM4EATMTSHRCYP1A2CYP3A4 | |
| SCHEMBL30709076 | 0.85 | KDM4E (0.70) | KDM4EATMTSHRCYP1A2CYP3A4 | |
| SCHEMBL506373 | 0.85 | CSNK2A1 (0.66) | KDM4EATMGLASMN1; SMN2MEN1 | |
| SCHEMBL8060167 | 0.83 | MEN1 (0.54) | KDM4EATMCYP1A2CYP3A4GLA | |
| Hydrochloric Acid SCHEMBL856874 | 0.83 | CSNK2A1 (0.67) | KDM4EATMGLASMN1; SMN2LMNA | |
| SCHEMBL210639 | 0.82 | ATM (1.00) | KDM4EATMTSHRCYP1A2CYP3A4 | |
| SCHEMBL29351641 | 0.82 | ATM (1.00) | KDM4EATMTSHRCYP1A2CYP3A4 | |
| SCHEMBL1042522 | 0.81 | KMT2A (0.57) | KDM4EATMTSHRCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210130349-A1 | NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2021-05-06 | — | — | US | disclosed |
| EP-3483149-B1 | BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | YUHAN CORP (KR) | 2021-01-13 | — | — | EP | disclosed |
| US-10626113-B2 | Phosphodiesterase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-04-21 | — | — | US | disclosed |
| US-10568320-B2 | Biologically-based control methods for insect pests | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2020-02-25 | — | — | US | disclosed |
| US-10568320-B2 | Biologically-based control methods for insect pests | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2020-02-25 | — | — | US | disclosed |
| EP-3022205-B1 | NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-02-05 | — | — | EP | disclosed |
| US-10383859-B2 | Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same | YUHAN CORPORATION (KR) | 2019-08-20 | — | — | US | disclosed |
| US-20190142809-A1 | Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same | YUHAN CORPORATION (KR) | 2019-05-16 | — | — | US | disclosed |
| EP-3483149-A1 | BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | Yuhan Corporation (KR) | 2019-05-15 | — | — | EP | disclosed |
| WO-2018160802-A1 | BIOLOGICALLY-BASED CONTROL METHODS FOR INSECT PESTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2018-09-07 | — | — | WO | disclosed |
| WO-1993013073-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |
| US-5130117-A | Imaging agents; monitor effectiveness of drugs in nervous and mental disorders | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1992-07-14 | — | — | US | disclosed |
| US-5068326-A | Agents for imaging human brains, 8-chloro-2,3,4,5-tetrahydro-3 -methyl-5-(4'-(125I)iodophenyl)-1H-3-benzazepine | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 1991-11-26 | — | — | US | disclosed |
| EP-0391554-A1 | Dopamine receptor ligands and imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1990-10-10 | — | — | EP | disclosed |
| US-4477378-A | ANTIDEPRESSANTS, NEUROLEPTIC AGENTS | SCHERING CORP. (US) | 1984-10-16 | — | — | US | disclosed |
| US-4349472-A | NEUROLEPTIC, ANTIDEPRESSANTS, SEDATIVES | SCHERING CORPORATION (US) | 1982-09-14 | — | — | US | disclosed |
| US-4284555-A | NEUROLEPTIC, ANTIDEPRESSANT, SEDATIVE | SCHERING CORPORATION (US) | 1981-08-18 | — | — | US | disclosed |
| EP-0005300-A1 | Substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, process for the preparation thereof, and pharmaceutical compositions containing them | Technobiotic Ltd. (CH) | 1979-11-14 | — | — | EP | disclosed |
| EP-0005299-A1 | Substituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, process for the preparation thereof, and pharmaceutical compositions containing them | Technobiotic Ltd. (CH) | 1979-11-14 | — | — | EP | disclosed |
| EP-0005298-A1 | Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, process for the preparation thereof, and pharmaceutical compositions containing them | Technobiotic Ltd. (CH) | 1979-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10568320-B2 | Biologically-based control methods for insect pests | PNMT, GAP43, PTMS | KDM4E 2397/4885ATM 4159/4885TSHR 262/4885 |
| US-20190142809-A1 | Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same | ILK, SBDS, BDKRB1 | KDM4E 1180/4885ATM 3741/4885TSHR 991/4885 |
| US-10383859-B2 | Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same | ILK, SBDS, BDKRB1 | KDM4E 1180/4885ATM 3741/4885TSHR 991/4885 |
| US-10626113-B2 | Phosphodiesterase inhibitors and uses thereof | PDE5A, PDE2A, PDE3A | KDM4E 328/4885ATM 2896/4885TSHR 4264/4885 |
| US-20210130349-A1 | NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | PDE5A, PDE2A, PDE3A | KDM4E 426/4885ATM 2932/4885TSHR 4112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.