Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.35 |
| ▸ | RELA | Q04206 | 4/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092012 | 0.81 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL6095372 | 0.81 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL7142807 | 0.78 | P2RY6 (0.38) | PTGS2PTGS1 | |
| SCHEMBL7142828 | 0.78 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL7148749 | 0.77 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL7149908 | 0.77 | PTGS1 (0.47) | PTGS2PTGS1 | |
| SCHEMBL7149312 | 0.77 | P2RY6 (0.54) | PTGS2PTGS1 | |
| SCHEMBL7148272 | 0.77 | POLB (0.48) | PTGS2PTGS1 | |
| SCHEMBL7143134 | 0.76 | P2RY6 (0.50) | PTGS2PTGS1KDM4EALDH1A1HPGD | |
| SCHEMBL7145364 | 0.75 | PTGS2 (0.44) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977748-B1 | SUBSTITUTED BENZOPYRAN DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2003-03-26 | — | — | EP | claimed |