Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.69 |
| ▸ | FLT3 | P36888 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 6/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.61 |
| ▸ | ACP1 | P24666 | 2/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL715268 | 0.88 | LMNA (0.61) | KITPDGFRAFLT3LMNAACHE | |
| SCHEMBL1085065 | 0.82 | ABCG2 (0.88) | LMNAACHEABCG2ACP1TSHR | |
| SCHEMBL713647 | 0.81 | KIT (1.00) | KITPDGFRAFLT3TAAR1 | |
| SCHEMBL14262907 | 0.79 | LMNA (1.00) | LMNAACHEABCG2ACP1TSHR | |
| SCHEMBL10029626 | 0.77 | KIT (0.66) | KITPDGFRAFLT3TAAR1 | |
| SCHEMBL4089260 | 0.76 | ACP1 (1.00) | LMNAACHEABCG2ACP1TSHR | |
| SCHEMBL715005 | 0.76 | ABCG2 (0.53) | KITPDGFRAFLT3ABCG2TSHR | |
| SCHEMBL6125247 | 0.75 | TSHR (0.84) | LMNAACHEABCG2ACP1TSHR | |
| SCHEMBL713670 | 0.75 | SLC6A7 (0.54) | LMNATSHRUSP2MEN1KMT2A | |
| SCHEMBL1083859 | 0.75 | ACP1 (1.00) | LMNAACHEABCG2ACP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609672-B2 | Piperazinylpyrimidine analogues as protein kinase inhibitors | UNIVERSITY OF THE PACIFIC (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2012027495-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | DCK, PAK5, CDK2 | KIT 964/4885PDGFRA 587/4885FLT3 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.