Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DNM2 | P50570 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22795638 | 0.95 | RAB9A (0.61) | HCAR3RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL12963036 | 0.87 | HCAR3 (0.56) | HCAR3RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL10632091 | 0.81 | HRH3 (0.47) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28152938 | 0.81 | RAB9A (0.50) | HCAR3RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL29969091 | 0.80 | EGFR (0.50) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL21512515 | 0.80 | EGFR (0.50) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL503269 | 0.80 | NPC1 (0.55) | HCAR3RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL22265370 | 0.79 | HCAR3 (0.59) | HCAR3RAB9AKDM4EALDH1A1CNR2 | |
| SCHEMBL7154180 | 0.79 | HCAR3 (0.59) | HCAR3RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15828788 | 0.79 | NPC1 (0.48) | HCAR3RAB9ANPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5453512-A | Bromination of acylaminopyridine with 2-acylaminopyridinium hydorbromide | ICHIKAWA GOSEI CHEMICAL CO., LTD. (JP) | 1995-09-26 | — | — | US | claimed |
| EP-0530524-A1 | Method of producing 2-amino-3-nitro-5-halogenopyridine | ICHIKAWA GOSEI CHEMICAL CO., LTD. (JP) | 1993-03-10 | — | — | EP | claimed |
| WO-2020248972-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF | JS INNOPHARM (SHANGHAI) LTD (CN) | 2020-12-17 | — | — | WO | disclosed |
| CN-106632016-A | Synthesis method of 2-acetamido-5-bromopyridine | 山东友帮生化科技有限公司 | 2017-05-10 | — | — | CN | disclosed |
| EP-0530524-B1 | Method of producing 2-amino-3-nitro-5-halogenopyridine | ICHIKAWA GOSEI KAGAKU KK (JP) | 2003-02-05 | — | — | EP | disclosed |
| US-5453512-A | Bromination of acylaminopyridine with 2-acylaminopyridinium hydorbromide | ICHIKAWA GOSEI CHEMICAL CO., LTD. (JP) | 1995-09-26 | — | — | US | disclosed |
| US-5290943-A | Halogenation of pyridine compound | ICHIKAWA GOSEI CHEMICAL CO., LTD. (JP) | 1994-03-01 | — | — | US | disclosed |
| EP-0530524-A1 | Method of producing 2-amino-3-nitro-5-halogenopyridine | ICHIKAWA GOSEI CHEMICAL CO., LTD. (JP) | 1993-03-10 | — | — | EP | disclosed |