Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | FPR1 | P21462 | 1/20 | 0.52 |
| ▸ | FPR2 | P25090 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7150779 | 0.81 | HTT (0.63) | NPC1RAB9AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL16054310 | 0.80 | ALDH1A1 (0.72) | NPC1RAB9AEPHX2KMT2ASMN1; SMN2 | |
| SCHEMBL7153529 | 0.78 | NPC1 (0.69) | NPC1RAB9AEPHX2KMT2AHPGD | |
| SCHEMBL5443184 | 0.78 | MAPT (0.57) | HPGDSMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL7152000 | 0.77 | SMN1; SMN2 (0.50) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL17507085 | 0.77 | SMN1; SMN2 (0.55) | NPC1RAB9AKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL7148309 | 0.77 | MAPT (0.68) | NPC1RAB9AEPHX2KMT2AHPGD | |
| SCHEMBL4745979 | 0.76 | KDM1A (0.49) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL4745975 | 0.76 | NPC1 (0.48) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL1677937 | 0.76 | GAA (0.64) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351938-A1 | PHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002057236-A1 | PHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | disclosed |