Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | CDK2 | P24941 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7153529 | 0.99 | NPC1 (0.69) | MAPTALDH1A1KDM4ENR4A1NPC1 | |
| SCHEMBL7154056 | 0.96 | ALDH1A1 (0.66) | MAPTALDH1A1KDM4ENR4A1NPC1 | |
| SCHEMBL7088328 | 0.88 | MAPT (0.68) | MAPTALDH1A1KDM4ENR4A1NPC1 | |
| SCHEMBL7149795 | 0.85 | USP2 (0.57) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7091303 | 0.84 | MAPT (0.66) | MAPTALDH1A1KDM4ENR4A1NPC1 | |
| SCHEMBL5163049 | 0.83 | NAMPT (0.48) | MAPTALDH1A1KDM4ENR4A1NPC1 | |
| SCHEMBL6140778 | 0.82 | MAPT (0.64) | MAPTALDH1A1KDM4ENR4A1NPC1 | |
| SCHEMBL7150779 | 0.82 | HTT (0.63) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7150787 | 0.82 | RAB9A (0.54) | MAPTALDH1A1KDM4ENR4A1NPC1 | |
| SCHEMBL7157379 | 0.82 | NPY2R (0.60) | MAPTALDH1A1KDM4ENR4A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351938-A1 | PHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-10-15 | — | — | EP | claimed |
| WO-2002057236-A1 | PHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | claimed |
| EP-1351938-A1 | PHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002057236-A1 | PHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | disclosed |