Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.54 |
| ▸ | PDE4A | P27815 | 8/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906195 | 0.77 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL27564379 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1GAATSHR | |
| SCHEMBL3371531 | 0.74 | PDE4D (0.69) | PDE4BPDE4APDE4CPDE4DNOX1 | |
| SCHEMBL6585141 | 0.74 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7916041 | 0.72 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7913459 | 0.72 | PDE4D (0.70) | PDE4BPDE4APDE4CPDE4DNOX1 | |
| SCHEMBL498539 | 0.71 | ALDH1A1 (0.60) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL7364665 | 0.70 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1157507 | 0.70 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL7441489 | 0.70 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934280-B1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |
| US-6051718-A | A PHOSPHODIESTERASE ENZYME INHIBITOR AND A CYTOKINE ANTAGONIST FOR TREATING ALLERGIC, ATOPIC AND INFLAMMATORY DISEASES INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-04-18 | — | — | US | disclosed |
| EP-0934280-A1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998014432-A1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-04-09 | — | — | WO | disclosed |