Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7152058 | 0.87 | NAMPT (0.49) | NAMPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL7152000 | 0.86 | SMN1; SMN2 (0.50) | NAMPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL1678146 | 0.84 | SMN1; SMN2 (0.54) | NAMPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL1677992 | 0.79 | MEN1 (0.60) | SMN1; SMN2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL6139947 | 0.74 | RAB9A (0.54) | NAMPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL30964182 | 0.74 | ALDH1A1 (0.76) | SMN1; SMN2RAB9AALDH1A1GAAL3MBTL1 | |
| SCHEMBL6140778 | 0.73 | MAPT (0.64) | SMN1; SMN2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL1380603 | 0.73 | F10 (0.59) | NAMPTALDH1A1 | |
| SCHEMBL7149483 | 0.73 | ALDH1A1 (0.43) | NAMPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL5631461 | 0.72 | F10 (0.61) | SMN1; SMN2RAB9AALDH1A1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4732757-B2 | — | — | 2011-07-27 | — | — | JP | claimed |
| EP-1490056-A1 | N-'4-(2-IMINO-PYRROLIDIN-1-YL)PHENYL)-ACETAMIDE AND CORRESPONDING PIPERIDINE DERIVATIVES AS FACTOR XA INHIBITORS FOR THE TREATMENT OF THROMBO-EMBOLIC DISEASES | MERCK PATENT GmbH (DE) | 2004-12-29 | — | — | EP | claimed |
| WO-2003084533-A1 | N-`4-(2-IMINO-PYRROLIDIN-1-YL)PHENYL!-ACETAMIDE AND CORRESPONDING PIPERIDINE DERIVATIVES AS FACTOR XA INHIBITORS FOR THE TREATMENT OF THROMBO-EMBOLIC DISEASES | MERCK PATENT GMBH (DE) | 2003-10-16 | — | — | WO | claimed |