Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.60 |
| ▸ | HTT | P42858 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | CASP7 | P55210 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7150009 | 0.88 | ALDH1A1 (0.60) | ALDH1A1HTTKDM4EGAAKMT2A | |
| SCHEMBL7155946 | 0.85 | ALDH1A1 (0.62) | ALDH1A1HTTKDM4EGAAKMT2A | |
| SCHEMBL3775925 | 0.79 | ALDH1A1 (0.83) | ALDH1A1HTTKDM4EGAAKMT2A | |
| SCHEMBL31152138 | 0.79 | ALDH1A1 (0.83) | ALDH1A1HTTKDM4EGAAKMT2A | |
| SCHEMBL7550691 | 0.78 | ALDH1A1 (0.64) | ALDH1A1HTTKDM4EGAAKMT2A | |
| SCHEMBL7248801 | 0.72 | ALDH1A1 (0.60) | ALDH1A1HTTKDM4EGAAKMT2A | |
| SCHEMBL14473838 | 0.72 | POLB (0.53) | ALDH1A1HTTKDM4EGAAKMT2A | |
| SCHEMBL3784471 | 0.71 | ALDH1A1 (1.00) | ALDH1A1HTTKDM4EGAAKMT2A | |
| SCHEMBL7742860 | 0.71 | KMT2A (0.46) | ALDH1A1HTTKDM4EGAAKMT2A | |
| SCHEMBL7875506 | 0.71 | ALDH1A1 (0.67) | ALDH1A1HTTKDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030176494-A1 | Novel coumarin and chromene compounds and methods of preparation and use thereof for treating or preventing viral infections | ADVANCED LIFE SCIENCES, INC. | 2003-09-18 | — | — | US | disclosed |
| WO-2003070159-A2 | NOVEL COUMARIN AND CHROMENE COMPOUNDS AND METHODS OF TREATING OR PREVENTING VIRAL INFECTIONS | SARAWAK MEDICHEM PHARMACEUTICALS (US) | 2003-08-28 | — | — | WO | disclosed |
| US-6420571-B2 | Methods for preparing antiviral calanolide compounds | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2002-07-16 | — | — | US | disclosed |
| US-6369241-B1 | MULTISTAGE REACTION OF KETOESTER WITH 1,3,5-TRIHYDROXYBENZENE TO PRODUCE DIHYDROXYOXOCOUMARONE, COUPLING AND CYCLIZATION | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2002-04-09 | — | — | US | disclosed |
| US-20020013480-A1 | Methods for preparing antiviral calanolide compounds | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2002-01-31 | — | — | US | disclosed |
| EP-1173442-A2 | METHODS FOR PREPARING ANTIVIRAL CALANOLIDE COMPOUNDS | Sarawak Medichem Pharmaceuticals Inc. (US) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064903-A2 | METHODS FOR PREPARING ANTIVIRAL CALANOLIDE COMPOUNDS | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 2000-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013480-A1 | Methods for preparing antiviral calanolide compounds | ZC3HAV1, ZC3HAV1L, CYP8B1 | ALDH1A1 911/4885HTT 4537/4885KDM4E 407/4885 |
| US-20030176494-A1 | Novel coumarin and chromene compounds and methods of preparation and use thereof for treating or preventing viral infections | HAVCR2, PROC, CTRC | ALDH1A1 2199/4885HTT 3290/4885KDM4E 3488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.