Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.49 |
| ▸ | MMP9 | P14780 | 10/20 | 0.41 |
| ▸ | MMP2 | P08253 | 9/20 | 0.41 |
| ▸ | MMP8 | P22894 | 4/20 | 0.40 |
| ▸ | MMP12 | P39900 | 3/20 | 0.40 |
| ▸ | MMP14 | P50281 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7152136 | 1.00 | ITGB3 (0.49) | ITGB3ITGA2BMMP9MMP2MMP8 | |
| SCHEMBL6778113 | 0.95 | ITGB3 (0.43) | ITGB3ITGA2BMMP9MMP2MMP8 | |
| SCHEMBL6778116 | 0.95 | ITGB3 (0.43) | ITGB3ITGA2BMMP9MMP2MMP8 | |
| SCHEMBL6622073 | 0.90 | ITGB3 (0.42) | ITGB3ITGA2BMMP9MMP2MMP8 | |
| SCHEMBL6622077 | 0.90 | ITGB3 (0.42) | ITGB3ITGA2BMMP9MMP2MMP8 | |
| SCHEMBL6622583 | 0.79 | ITGB3 (0.49) | ITGB3ITGA2BMMP9MMP2MMP14 | |
| SCHEMBL6622584 | 0.79 | ITGB3 (0.49) | ITGB3ITGA2BMMP9MMP2MMP14 | |
| SCHEMBL7147856 | 0.78 | MMP2 (0.58) | ITGB3ITGA2BMMP9MMP2MMP8 | |
| Hydrochloric Acid SCHEMBL6622243 | 0.77 | ITGB3 (0.55) | ITGB3ITGA2BMMP9MMP2MMP8 | |
| SCHEMBL6620316 | 0.77 | ITGB3 (0.51) | ITGB3ITGA2BMMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6528534-B2 | Useful as glycoprotein IIb/IIIa antagonists for prophylaxis thrombosis, therapy of atheroschlerosis, arterioschlerosis, acute myocardial infarction, chronic stable angina, unstable angina, transient ischemic attacks and strokes | MILLENNIUM PHARMACEUTICALS, INC. | 2003-03-04 | — | — | US | disclosed |