Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9124237 | 0.82 | TDP1 (0.53) | TDP1ATMALDH1A1TSHRHSD17B10 | |
| SCHEMBL7146887 | 0.81 | TDP1 (0.50) | TDP1ATMALDH1A1TSHRHSD17B10 | |
| SCHEMBL11074682 | 0.77 | TSHR (0.71) | TDP1ALDH1A1TSHRHSD17B10CES1 | |
| SCHEMBL28712215 | 0.75 | ATM (0.44) | TDP1ATMALDH1A1TSHRCES1 | |
| SCHEMBL506074 | 0.74 | TDP1 (0.53) | TDP1ATMALDH1A1TSHRHSD17B10 | |
| SCHEMBL3875454 | 0.74 | TDP1 (0.58) | TDP1ATMALDH1A1TSHRHSD17B10 | |
| SCHEMBL906344 | 0.74 | TDP1 (0.46) | TDP1ATMALDH1A1CES1LMNA | |
| SCHEMBL30109423 | 0.73 | AKR1C1 (0.54) | TDP1ALDH1A1TSHRHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL31332428 | 0.73 | TDP1 (0.57) | TDP1ATMALDH1A1TSHRHSD17B10 | |
| SCHEMBL5132603 | 0.72 | TDP1 (0.56) | TDP1ATMALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309590-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-05-14 | — | — | EP | disclosed |
| WO-2001098299-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | disclosed |