Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7153128 | 0.81 | TDP1 (0.51) | TDP1ATMCES1LMNAF2 | |
| SCHEMBL3875454 | 0.81 | TDP1 (0.58) | TDP1ATMCES1LMNAF2 | |
| Hydrochloric Acid SCHEMBL31332428 | 0.79 | TDP1 (0.57) | TDP1ATMCES1LMNAF2 | |
| SCHEMBL9124237 | 0.77 | TDP1 (0.53) | TDP1ATMCES1LMNAF2 | |
| SCHEMBL506074 | 0.77 | TDP1 (0.53) | TDP1ATMCES1LMNAF2 | |
| SCHEMBL906344 | 0.77 | TDP1 (0.46) | TDP1ATMCES1LMNAF2 | |
| Carbamic Acid SCHEMBL28106682 | 0.77 | TDP1 (0.54) | TDP1ATMLMNAF2ALDH1A1 | |
| SCHEMBL5132603 | 0.75 | TDP1 (0.56) | TDP1ATMCES1LMNAF2 | |
| SCHEMBL16618550 | 0.75 | CES1 (0.41) | TDP1ATMCES1LMNAF2 | |
| SCHEMBL219676 | 0.75 | LMNA (0.56) | TDP1CES1LMNAF2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309590-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-05-14 | — | — | EP | disclosed |
| WO-2001098299-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | disclosed |