Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNMT | Q14749 | 3/20 | 0.73 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.66 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.66 |
| ▸ | PNMT | P11086 | 1/20 | 0.66 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.66 |
| ▸ | AHCY | P23526 | 6/20 | 0.66 |
| ▸ | NADK | O95544 | 1/20 | 0.66 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.65 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.64 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054701 | 0.88 | GNMT (0.74) | GNMTDOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL6907266 | 0.88 | GNMT (0.74) | GNMTDOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL6902821 | 0.88 | GNMT (0.74) | GNMTDOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL7054700 | 0.88 | GNMT (0.74) | GNMTDOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL19434095 | 0.88 | GNMT (0.80) | GNMTDOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL6901855 | 0.88 | GNMT (0.80) | GNMTDOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL9550942 | 0.88 | GNMT (0.80) | GNMTDOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL17551942 | 0.88 | GNMT (0.80) | GNMTDOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL6907846 | 0.87 | AHCY (0.68) | GNMTDOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL6907702 | 0.85 | METTL3 (0.70) | DOT1LAHCYNADKSLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482977-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003074083-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2003-09-12 | — | — | WO | disclosed |