Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805078 | 0.99 | POLB (0.57) | POLBALDH1A1KMT2AATMHSP90AA1 | |
| Hydrochloric Acid SCHEMBL6574257 | 0.87 | POLB (0.57) | POLBALDH1A1KMT2AATMHSP90AA1 | |
| SCHEMBL6573637 | 0.86 | POLB (0.55) | POLBALDH1A1KMT2AATMHSP90AA1 | |
| Hydrochloric Acid SCHEMBL7154981 | 0.84 | L3MBTL1 (0.51) | POLBALDH1A1KMT2AHSP90AA1MEN1 | |
| SCHEMBL7806186 | 0.83 | L3MBTL1 (0.49) | POLBALDH1A1KMT2AHSP90AA1MEN1 | |
| Hydrochloric Acid SCHEMBL6940856 | 0.82 | POLB (0.60) | POLBALDH1A1KMT2AATMHSP90AA1 | |
| Hydrochloric Acid SCHEMBL6942987 | 0.82 | POLB (0.60) | POLBALDH1A1KMT2AATMHSP90AA1 | |
| Hydrochloric Acid SCHEMBL6946096 | 0.82 | POLB (0.60) | POLBALDH1A1KMT2AATMHSP90AA1 | |
| Hydrochloric Acid SCHEMBL6941908 | 0.82 | POLB (0.60) | POLBALDH1A1KMT2AATMHSP90AA1 | |
| SCHEMBL6806837 | 0.81 | ALDH1A1 (0.66) | ALDH1A1KMT2AMEN1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | claimed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | disclosed |