Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3052651 | 0.81 | CYP19A1 (0.59) | CCR2CYP19A1ALDH1A1MAPTKDM4E | |
| SCHEMBL29697822 | 0.79 | CCR2 (0.52) | CCR2CYP19A1TP53HTTALDH1A1 | |
| SCHEMBL28808282 | 0.78 | CCR2 (0.47) | CCR2CYP19A1ALDH1A1MAPTMAOA | |
| SCHEMBL1415761 | 0.78 | CCR2 (0.63) | CCR2CYP19A1TP53HTTMAPT | |
| SCHEMBL8045718 | 0.77 | CCR2 (0.47) | CCR2ALDH1A1MAPTTDP1CYP3A4 | |
| SCHEMBL4303543 | 0.77 | MCL1 (0.65) | ALDH1A1KDM4EHPGDHSD17B10MCL1 | |
| SCHEMBL9541803 | 0.76 | CYP1A2 (0.44) | CCR2CYP19A1HTTALDH1A1MAPT | |
| SCHEMBL3638474 | 0.76 | POLB (0.43) | TP53HTTALDH1A1MAPTKDM4E | |
| SCHEMBL6018883 | 0.76 | CCR2 (0.61) | CCR2CYP19A1TP53HTTALDH1A1 | |
| SCHEMBL15712653 | 0.75 | CCR2 (0.60) | CCR2CYP19A1TP53HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534660-B1 | Halogenation, alkylation and ring-closure of protected 2-amino-4-hydroxynaphthalene under suitable conditions to provide desired racemate, isolating (-) isomer, removing protecting groups | IMMUNOGEN, INC. | 2003-03-18 | — | — | US | disclosed |