Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7155162 | 0.76 | CCR2 (0.51) | POLBKMT2AMAPTALDH1A1PKM | |
| SCHEMBL15532179 | 0.73 | KMT2A (0.52) | KMT2AMAPTALDH1A1LMNAPKM | |
| SCHEMBL28679353 | 0.72 | MAPT (0.43) | KMT2AMAPTALDH1A1LMNAPKM | |
| SCHEMBL21093059 | 0.70 | MAPT (0.57) | POLBKMT2AMAPTALDH1A1LMNA | |
| SCHEMBL5122161 | 0.69 | ALDH1A1 (0.40) | KMT2AMAPTALDH1A1LMNAPKM | |
| SCHEMBL5122165 | 0.69 | ALDH1A1 (0.40) | KMT2AMAPTALDH1A1LMNAPKM | |
| SCHEMBL15534813 | 0.68 | KMT2A (0.60) | KMT2AMAPTALDH1A1LMNAPKM | |
| SCHEMBL12732375 | 0.68 | ALDH1A1 (0.56) | KMT2AMAPTALDH1A1LMNAPKM | |
| SCHEMBL19911558 | 0.68 | HCAR3 (0.55) | KMT2AMAPTALDH1A1LMNAPKM | |
| SCHEMBL29613728 | 0.68 | ALDH1A1 (0.56) | KMT2AMAPTALDH1A1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |