Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7150527 | 0.76 | LMNA (0.70) | ESR1ESR2LMNAMAPK1KDM4E | |
| SCHEMBL4958333 | 0.76 | LMNA (0.73) | LMNAMAPK1TLR7 | |
| SCHEMBL12707221 | 0.74 | IRAK4 (0.45) | KDM4ETLR7TLR8 | |
| SCHEMBL6701015 | 0.73 | SIRT2 (0.68) | ESR1ESR2LMNAKDM4E | |
| SCHEMBL8433990 | 0.72 | MEN1 (0.42) | LMNAMAPK1KDM4ETLR7TLR8 | |
| SCHEMBL22160860 | 0.72 | KDM4E (0.52) | LMNAKDM4E | |
| SCHEMBL8537440 | 0.71 | ALDH1A1 (0.44) | LMNAKDM4ETLR7TLR8 | |
| SCHEMBL5117321 | 0.70 | ESR2 (1.00) | ESR1ESR2LMNAMAPK1 | |
| SCHEMBL25177372 | 0.70 | TLR7 (0.78) | TLR7TLR8 | |
| SCHEMBL24688398 | 0.70 | KDM4E (0.74) | KDM4ETLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672031-B1 | CATECHOL DIETHERS AS SELECTIVE PDE IV INHIBITORS | PFIZER (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |