Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BRD1 | O95696 | 2/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.41 |
| ▸ | BRPF3 | Q9ULD4 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7798697 | 0.99 | TRIM24 (0.44) | TRIM24MCOLN2MCOLN3MCOLN1HTR6 | |
| Hydrochloric Acid SCHEMBL7156926 | 0.87 | KMT2A (0.42) | HTR6KMT2ALMNAMEN1MAPT | |
| Hydrochloric Acid SCHEMBL6573313 | 0.87 | ALDH1A1 (0.41) | KMT2ALMNAMEN1MAPTSMN1; SMN2 | |
| SCHEMBL7798700 | 0.86 | KMT2A (0.43) | HTR6KMT2ALMNAMEN1MAPT | |
| SCHEMBL6575877 | 0.86 | MEN1 (0.42) | KMT2ALMNAMEN1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7158538 | 0.83 | MCL1 (0.48) | HTR6KMT2ALMNAMEN1MAPT | |
| SCHEMBL7798719 | 0.82 | MCL1 (0.48) | HTR6KMT2ALMNAMEN1MAPT | |
| Hydrochloric Acid SCHEMBL7158543 | 0.82 | G6PD (0.38) | KMT2AMEN1MAPTALDH1A1RECQL | |
| Hydrochloric Acid SCHEMBL6939671 | 0.82 | KMT2A (0.40) | KMT2ALMNAMEN1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6943709 | 0.82 | GAA (0.42) | KMT2ALMNAMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | claimed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | disclosed |