Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158260 | 1.00 | CTSS (0.50) | CTSSSMN1; SMN2SYKKMT2AMEN1 | |
| SCHEMBL7154600 | 0.92 | CTSS (0.46) | CTSSSMN1; SMN2SYKKMT2AMEN1 | |
| SCHEMBL7154604 | 0.92 | CTSS (0.46) | CTSSSMN1; SMN2SYKKMT2AMEN1 | |
| SCHEMBL7158550 | 0.92 | CA1 (0.46) | CTSSSYKKMT2AMEN1CTSL | |
| SCHEMBL7158545 | 0.92 | CA1 (0.46) | CTSSSYKKMT2AMEN1CTSL | |
| SCHEMBL7411667 | 0.89 | CTSS (0.53) | CTSSSMN1; SMN2SYKKMT2AMEN1 | |
| SCHEMBL7411664 | 0.89 | CTSS (0.53) | CTSSSMN1; SMN2SYKKMT2AMEN1 | |
| SCHEMBL6666953 | 0.86 | CTSS (0.50) | CTSSSMN1; SMN2SYKKMT2AMEN1 | |
| SCHEMBL6664291 | 0.83 | CRHBP (0.52) | CTSSSMN1; SMN2SYKKMT2AMEN1 | |
| SCHEMBL8381862 | 0.81 | CTSS (0.53) | CTSSSMN1; SMN2SYKKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6635621-B1 | Alpha amino acid amide derivatives; reducing cathepsins B, L, S and/or K activity | NAEJA PHARMACEUTICAL INC. (CA) | 2003-10-21 | — | — | US | disclosed |