Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7164317 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1RAB9ANPC1PKM | |
| SCHEMBL7164659 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1GAAMAPTMEN1 | |
| SCHEMBL6779548 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1RAB9ANPC1PKM | |
| SCHEMBL7161779 | 0.83 | L3MBTL1 (0.40) | SMN1; SMN2L3MBTL1RAB9ANPC1PKM | |
| SCHEMBL7169154 | 0.82 | SMN1; SMN2 (0.37) | SMN1; SMN2L3MBTL1RAB9ANPC1PKM | |
| SCHEMBL7163316 | 0.82 | SMN1; SMN2 (0.37) | SMN1; SMN2L3MBTL1RAB9ANPC1PKM | |
| SCHEMBL7168150 | 0.82 | POLB (0.39) | SMN1; SMN2L3MBTL1RAB9ANPC1PKM | |
| Hydrochloric Acid SCHEMBL7164634 | 0.82 | TMPRSS15 (0.41) | SMN1; SMN2L3MBTL1RAB9ANPC1PKM | |
| SCHEMBL7168620 | 0.81 | NQO2 (0.48) | — | |
| Hydrochloric Acid SCHEMBL7160278 | 0.81 | TMPRSS15 (0.41) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966454-B1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-05-07 | — | — | EP | disclosed |
| EP-0966454-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037075-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-08-27 | — | — | WO | disclosed |