Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159692 | 0.88 | KIT (0.40) | KIT | |
| SCHEMBL7160676 | 0.88 | MAPK1 (0.39) | PDE3BPDE3AAKT1 | |
| SCHEMBL7163194 | 0.88 | TP53 (0.34) | PDE3BPDE3AKITPDGFRB | |
| SCHEMBL7156878 | 0.86 | PDE10A (0.36) | PDE3BPDE3APDE10AHRH3PDGFRB | |
| SCHEMBL7159348 | 0.85 | HTT (0.33) | NPSR1 | |
| SCHEMBL5202556 | 0.81 | DHFR (0.35) | — | |
| SCHEMBL7164355 | 0.79 | PDE3B (0.34) | PDE3BPDE3AKITNPSR1 | |
| SCHEMBL7164341 | 0.78 | PDE2A (0.34) | PDE3BPDE3AKITNPSR1 | |
| SCHEMBL7163401 | 0.77 | ALDH1A1 (0.42) | PDE3BPDE3AAKT1AKT2AKT3 | |
| SCHEMBL7159326 | 0.74 | MAPK1 (0.39) | AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | claimed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | disclosed |