Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7164341 | 0.90 | PDE2A (0.34) | HTTALDH1A1NPSR1KDM4EPDE2A | |
| SCHEMBL7163401 | 0.89 | ALDH1A1 (0.42) | HTTALDH1A1NPSR1KDM4ESMN1; SMN2 | |
| SCHEMBL7160303 | 0.87 | CCR5 (0.36) | HTTALDH1A1NPSR1KDM4ERECQL | |
| SCHEMBL7164355 | 0.86 | PDE3B (0.34) | HTTALDH1A1NPSR1KDM4EKMT2A | |
| SCHEMBL7163517 | 0.85 | RPS6KB1 (0.40) | HTTALDH1A1NPSR1HPGDSMN1; SMN2 | |
| SCHEMBL7159488 | 0.85 | PDE3B (0.35) | NPSR1 | |
| SCHEMBL5207721 | 0.84 | TRAP1 (0.36) | RECQL | |
| SCHEMBL7160676 | 0.80 | MAPK1 (0.39) | HTTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7159379 | 0.76 | PIK3CA (0.36) | HTTALDH1A1NPSR1KDM4EPDE2A | |
| SCHEMBL7163830 | 0.76 | ALDH1A1 (0.43) | HTTALDH1A1NPSR1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | claimed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | disclosed |